We sometimes get asked "do we follow the Adobe ePub best practices guide?". Our answer is "we have our own ePub best practices guides which have been formulated producing a lot more content than the authors of the Adobe guide.
The Adobe best practices was written two years ago. It specifically addresses an Adobe viewpoint of ePub and are showing their age, except where they apply to reader/device limitations. Having said that, most of the Adobe guide is pretty much simple common sense but oriented to trade novel type documents. There is a lot more content out there!
Because ADE (Adobe Digital Editions) is possibly the most widely distributed ePub reader to date, and the one with the best DRM support, we live with it and have to compromise ePub production to live with its limitations.
When we create ePubs for publishers new to ePub and devices we get the same set of questions about why e-pubs look and behave the way they do. Here is some practical information from the e-pub production coal-face.